Drug General Information
Drug ID	D0V9KF
Former ID	DNC005082
Drug Name	8-(3,3,3-trifluoropropoxy)quinolin-2-amine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527194]
Structure		Download 2D MOL 3D MOL
Formula	C12H11F3N2O
Canonical SMILES	C1=CC2=C(C(=C1)OCCC(F)(F)F)N=C(C=C2)N
InChI	1S/C12H11F3N2O/c13-12(14,15)6-7-18-9-3-1-2-8-4-5-10(16)17-11(8)9/h1-5H,6-7H2,(H2,16,17)
InChIKey	ZGZSZXFSLMTFBX-UHFFFAOYSA-N
PubChem Compound ID	22254540
Target and Pathway
Target(s)	Melanin-concentrating hormone receptor 1	Target Info	Inhibitor	[527194]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Peptide ligand-binding receptors
	G alpha (q) signalling events
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 527194	Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7.Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1.
Ref 527194	Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7.Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1.

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