Drug Information

Drug General Information
Drug ID
D02UVR
Former ID
DIB018980
Drug Name
bisandrographolide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539625]
Structure
Download
2D MOL
Formula
C40H56O8
InChI
InChI=1S/C40H56O8/c1-23-7-11-31-37(3,16-13-33(43)39(31,5)21-41)28(23)10-9-25-19-30(48-35(25)45)27(26-15-18-47-36(26)46)20-29-24(2)8-12-32-38(29,4)17-14-34(44)40(32,6)22-42/h9-10,15,19,27-34,41-44H,1-2,7-8,11-14,16-18,20-22H2,3-6H3/b10-9+/t27?,28-,29-,30?,31+,32+,33-,34-,37+,38+,39+,40+/m1/s1
InChIKey
WQHWOZANSOUSAY-LZBAHHAZSA-N
PubChem Compound ID
12000062
PubChem Substance ID
17499254, 37448436, 53801077, 75794422, 252511018, 252511022
Target and Pathway
Target(s) Transient receptor potential cation channel subfamily V member 4 Target Info Activator [528361]
KEGG Pathway Inflammatory mediator regulation of TRP channels
Reactome TRP channels
References
Ref 539625(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2502).
Ref 528361Bisandrographolide from Andrographis paniculata activates TRPV4 channels. J Biol Chem. 2006 Oct 6;281(40):29897-904. Epub 2006 Aug 9.

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