Drug Information

Drug General Information
Drug ID
D02NWL
Former ID
DIB018157
Drug Name
[125I]iodoaminopotentidine
Synonyms
[125I]APT; Iodoaminopotentidine; [125I]-iodoaminopotentidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538743]
Structure
Download
2D MOL
Formula
C26H34IN7O2
InChI
InChI=1S/C26H34IN7O2/c27-23-17-21(8-9-24(23)29)25(35)30-11-12-32-26(33-19-28)31-10-5-15-36-22-7-4-6-20(16-22)18-34-13-2-1-3-14-34/h4,6-9,16-17H,1-3,5,10-15,18,29H2,(H,30,35)(H2,31,32,33)/i27-2
InChIKey
VJTYCMQYDRXNNY-ALRLDUCRSA-N
PubChem Compound ID
73755000
PubChem Substance ID
135651102
Target and Pathway
Target(s) Histamine H2 receptor Target Info Antagonist [534291]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 538743(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1230).
Ref 534291G proteins of the Gq family couple the H2 histamine receptor to phospholipase C. Mol Endocrinol. 1996 Dec;10(12):1697-707.

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