| Drug General Information |
| Drug ID |
D0RG0Z
|
| Former ID |
DIB019045
|
| Drug Name |
BX-795
|
| Synonyms |
BX795; BX 795
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C23H26IN7O2S
|
| InChI |
InChI=1S/C23H26IN7O2S/c24-18-15-27-22(30-20(18)25-9-5-10-26-21(32)19-8-4-13-34-19)28-16-6-3-7-17(14-16)29-23(33)31-11-1-2-12-31/h3-4,6-8,13-15H,1-2,5,9-12H2,(H,26,32)(H,29,33)(H2,25,27,28,30)
|
| InChIKey |
VAVXGGRQQJZYBL-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
15062621, 22491924, 39137046, 46517281, 57646320, 74665967, 103694293, 125327985, 125571004, 135685264, 135685265, 135685284, 135685914, 135697746, 136023426, 136340378, 136367516, 136368018, 136946513, 137275887, 137275888, 137410013, 143283778, 144115770, 152159570, 152258240, 152344403, 160647076, 161003745, 161003747, 161004904, 161004906, 162011957, 163124921, 163614961, 163685634, 163781154, 172652489, 174560986, 177748510, 180371703, 186007044, 188941733, 204378137, 218927672, 223679383, 223704302, 229844287, 242060380, 244808971
|
| Target and Pathway |
| Target(s) |
Protein kinase A |
Target Info |
Inhibitor |
[2]
|
|---|
| Serine/threonine-protein kinase Chk1 |
Target Info |
Inhibitor |
[2]
|
| Cell division protein kinase 2 |
Target Info |
Inhibitor |
[2]
|
| Vascular endothelial growth factor receptor 2 |
Target Info |
Inhibitor |
[2]
|
| 3-phosphoinositide dependent protein kinase-1 |
Target Info |
Inhibitor |
[2]
|
| Glycogen synthase kinase-3 beta |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
Cell cycle
|
|
p53 signaling pathway
|
|
HTLV-I infection
|
|
Viral carcinogenesishsa04068:FoxO signaling pathway
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|
Oocyte meiosis
|
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PI3K-Akt signaling pathway
|
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Progesterone-mediated oocyte maturation
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Hepatitis B
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Measles
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Herpes simplex infection
|
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Epstein-Barr virus infection
|
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Pathways in cancer
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Viral carcinogenesis
|
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Prostate cancer
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Small cell lung cancerhsa04014:Ras signaling pathway
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Rap1 signaling pathway
|
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Cytokine-cytokine receptor interaction
|
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Endocytosis
|
|
VEGF signaling pathway
|
|
Focal adhesion
|
|
Proteoglycans in cancerhsa03320:PPAR signaling pathway
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|
FoxO signaling pathway
|
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Sphingolipid signaling pathway
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|
mTOR signaling pathway
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AMPK signaling pathway
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T cell receptor signaling pathway
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Fc epsilon RI signaling pathway
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Neurotrophin signaling pathway
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Insulin signaling pathway
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Thyroid hormone signaling pathway
|
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Aldosterone-regulated sodium reabsorption
|
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Toxoplasmosis
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Hepatitis C
|
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Proteoglycans in cancer
|
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Endometrial cancer
|
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Non-small cell lung cancer
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Choline metabolism in cancerhsa04012:ErbB signaling pathway
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Chemokine signaling pathway
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|
Wnt signaling pathway
|
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Hedgehog signaling pathway
|
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Axon guidance
|
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Hippo signaling pathway
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Signaling pathways regulating pluripotency of stem cells
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B cell receptor signaling pathway
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Dopaminergic synapse
|
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Melanogenesis
|
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Prolactin signaling pathway
|
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Non-alcoholic fatty liver disease (NAFLD)
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Alzheimer's disease
|
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Influenza A
|
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Colorectal cancer
|
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Basal cell carcinoma
|
|
NetPath Pathway
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TCR Signaling PathwayNetPath_14:IL2 Signaling Pathway
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PANTHER Pathway
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p53 pathway
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p53 pathway feedback loops 2P00005:Angiogenesis
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VEGF signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway
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Insulin/IGF pathway-protein kinase B signaling cascade
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Interleukin signaling pathway
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PDGF signaling pathway
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PI3 kinase pathway
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Ras Pathway
|
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p53 pathway feedback loops 2
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CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
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Angiogenesis
|
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Cadherin signaling pathway
|
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Hedgehog signaling pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Wnt signaling pathway
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CCKR signaling map ST
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Pathway Interaction Database
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Fanconi anemia pathway
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p73 transcription factor network
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ATR signaling pathway
|
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Circadian rhythm pathway
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p53 pathwaysmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
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Signaling events mediated by PRL
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E2F transcription factor network
|
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mTOR signaling pathway
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IL2-mediated signaling events
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FoxO family signaling
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FOXM1 transcription factor network
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BARD1 signaling events
|
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p53 pathway
|
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Regulation of retinoblastoma proteinhif2pathway:HIF-2-alpha transcription factor network
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Beta3 integrin cell surface interactions
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Signaling events mediated by TCPTP
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SHP2 signaling
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S1P1 pathway
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VEGF and VEGFR signaling network
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Integrins in angiogenesis
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Signaling events mediated by VEGFR1 and VEGFR2
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Notch-mediated HES/HEY networkbcr_5pathway:BCR signaling pathway
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Insulin Pathway
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TCR signaling in naï
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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TCR signaling in naï
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FAS (CD95) signaling pathway
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CXCR4-mediated signaling events
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IGF1 pathway
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Class I PI3K signaling events
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ErbB1 downstream signaling
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IL8- and CXCR2-mediated signaling events
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CXCR3-mediated signaling events
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VEGFR1 specific signals
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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Class I PI3K signaling events mediated by Akt
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IL8- and CXCR1-mediated signaling events
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Trk receptor signaling mediated by PI3K and PLC-gamma
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FGF signaling pathway
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TGF-beta receptor signalinglysophospholipid_pathway:LPA receptor mediated events
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Degradation of beta catenin
|
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Reelin signaling pathway
|
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Presenilin action in Notch and Wnt signaling
|
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Integrin-linked kinase signaling
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CDC42 signaling events
|
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LKB1 signaling events
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Canonical Wnt signaling pathway
|
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Glucocorticoid receptor regulatory network
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C-MYC pathway
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Regulation of Androgen receptor activity
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BMP receptor signaling
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Hedgehog signaling events mediated by Gli proteins
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Validated transcriptional targets of deltaNp63 isoforms
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Aurora A signaling
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Insulin-mediated glucose transport
|
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PathWhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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Insulin Signalling
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Reactome
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Activation of ATR in response to replication stress
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Processing of DNA double-strand break ends
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Presynaptic phase of homologous DNA pairing and strand exchange
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G2/M DNA damage checkpoint
|
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Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
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Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-1538133:G0 and Early G1
|
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Regulation of APC/C activators between G1/S and early anaphase
|
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SCF(Skp2)-mediated degradation of p27/p21
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Senescence-Associated Secretory Phenotype (SASP)
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DNA Damage/Telomere Stress Induced Senescence
|
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G2 Phase
|
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Orc1 removal from chromatin
|
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Cyclin E associated events during G1/S transition
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Cyclin A/B1 associated events during G2/M transition
|
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p53-Dependent G1 DNA Damage Response
|
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Cyclin A:Cdk2-associated events at S phase entry
|
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Meiotic recombination
|
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Factors involved in megakaryocyte development and platelet productionR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
|
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VEGF binds to VEGFR leading to receptor dimerization
|
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Integrin cell surface interactions
|
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EPHA-mediated growth cone collapse
|
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VEGFA-VEGFR2 Pathway
|
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VEGFR2 mediated cell proliferationR-HSA-114604:GPVI-mediated activation cascade
|
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PIP3 activates AKT signaling
|
|
Activation of AKT2
|
|
Role of LAT2/NTAL/LAB on calcium mobilization
|
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FCERI mediated NF-kB activation
|
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Integrin alphaIIb beta3 signaling
|
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CD28 dependent PI3K/Akt signaling
|
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CTLA4 inhibitory signaling
|
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G beta:gamma signalling through PI3Kgamma
|
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VEGFR2 mediated vascular permeability
|
|
VEGFR2 mediated cell proliferation
|
|
CLEC7A (Dectin-1) signaling
|
|
RHO GTPases activate PKNs
|
|
Constitutive Signaling by AKT1 E17K in CancerR-HSA-195253:Degradation of beta-catenin by the destruction complex
|
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AKT phosphorylates targets in the cytosol
|
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Regulation of HSF1-mediated heat shock response
|
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CRMPs in Sema3A signaling
|
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Disassembly of the destruction complex and recruitment of AXIN to the membrane
|
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S33 mutants of beta-catenin aren't phosphorylated
|
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S37 mutants of beta-catenin aren't phosphorylated
|
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S45 mutants of beta-catenin aren't phosphorylated
|
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T41 mutants of beta-catenin aren't phosphorylated
|
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Degradation of GLI2 by the proteasome
|
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Constitutive Signaling by AKT1 E17K in Cancer
|
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WikiPathways
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DNA Damage Response
|
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Signaling by SCF-KIT
|
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ATM Signaling Pathway
|
|
Retinoblastoma (RB) in Cancer
|
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Integrated Pancreatic Cancer Pathway
|
|
Prostate Cancer
|
|
Integrated Breast Cancer Pathway
|
|
Integrated Cancer pathway
|
|
Cell Cycle
|
|
Cell Cycle Checkpoints
|
|
miRNA Regulation of DNA Damage ResponseWP707:DNA Damage Response
|
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ID signaling pathway
|
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DNA Replication
|
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G1 to S cell cycle control
|
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M/G1 Transition
|
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S Phase
|
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Meiotic Recombination
|
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Aryl Hydrocarbon Receptor
|
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Spinal Cord Injury
|
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Oncostatin M Signaling Pathway
|
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Signaling Pathways in Glioblastoma
|
|
TSH signaling pathway
|
|
Synthesis of DNA
|
|
Regulation of DNA replication
|
|
Mitotic G2-G2/M phases
|
|
Mitotic G1-G1/S phases
|
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Factors involved in megakaryocyte development and platelet production
|
|
APC/C-mediated degradation of cell cycle proteins
|
|
miRNA Regulation of DNA Damage ResponseWP306:Focal Adhesion
|
|
Nifedipine Activity
|
|
Cardiac Progenitor Differentiation
|
|
Signaling by VEGF
|
|
AngiogenesisWP722:Serotonin HTR1 Group and FOS Pathway
|
|
TCR Signaling Pathway
|
|
Insulin Signaling
|
|
EGF/EGFR Signaling Pathway
|
|
Focal Adhesion
|
|
Cardiac Hypertrophic Response
|
|
Fc epsilon receptor (FCERI) signaling
|
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
|
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
|
PIP3 activates AKT signaling
|
|
BDNF signaling pathway
|
|
Interleukin-11 Signaling Pathway
|
|
B Cell Receptor Signaling Pathway
|
|
TCR signaling
|
|
Signaling by Insulin receptor
|
|
Integrin-mediated Cell Adhesion
|
|
GPVI-mediated activation cascade
|
|
GPCR downstream signaling
|
|
Costimulation by the CD28 family
|
|
MicroRNAs in cardiomyocyte hypertrophyWP710:DNA Damage Response (only ATM dependent)
|
|
Senescence and Autophagy in Cancer
|
|
Notch Signaling Pathway
|
|
Glycogen Metabolism
|
|
Wnt Signaling Pathway
|
|
Wnt Signaling Pathway and Pluripotency
|
|
IL-6 signaling pathway
|
|
Wnt Signaling Pathway Netpath
|
|
Copper homeostasis
|
|
Hair Follicle Development: Induction (Part 1 of 3)
|
|
Degradation of beta-catenin by the destruction complex
|
|
T-Cell Receptor and Co-stimulatory Signaling
|
|
Corticotropin-releasing hormone
|
|
IL17 signaling pathway
|
|
Neural Crest Differentiation
|
|
Alzheimers Disease
|
|
IL-7 Signaling Pathway
|
|
Regulation of Microtubule Cytoskeleton
|
|
TWEAK Signaling Pathway
|
|
Leptin signaling pathway
|
|
Semaphorin interactions
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
|
Androgen receptor signaling pathway
|
|
IL-5 Signaling Pathway
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8006). |
|---|
| REF 2 | Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280(20):19867-74. Epub 2005 Mar 16. |
|---|
