Drug Information

Drug General Information
Drug ID
D0F1ZE
Former ID
DNC011983
Drug Name
2-Naphthalen-1-ylmethyl-1,2-dihydro-indazol-3-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529474]
Structure
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2D MOL

3D MOL
Formula
C18H14N2O
Canonical SMILES
C1=CC=C2C(=C1)C=CC=C2CN3C(=O)C4=CC=CC=C4N3
InChI
1S/C18H14N2O/c21-18-16-10-3-4-11-17(16)19-20(18)12-14-8-5-7-13-6-1-2-9-15(13)14/h1-11,19H,12H2
InChIKey
SXKBSXCUDSHBDF-UHFFFAOYSA-N
PubChem Compound ID
14898710
Target and Pathway
Target(s) Arachidonate 5-lipoxygenase Target Info Inhibitor [529474]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 529474J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity.
Ref 529474J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity.

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