| Drug General Information |
| Drug ID |
D03CPB
|
| Former ID |
DIB020811
|
| Drug Name |
RKI-1447
|
| Synonyms |
RKI1447; compound 5g [PMID 23275831]
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C16H14N4O2S
|
| InChI |
InChI=1S/C16H14N4O2S/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12/h1-8,10,21H,9H2,(H2,18,19,20,22)
|
| InChIKey |
GDVRVPIXWXOKQO-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
143472448, 162112107, 172660019, 175426346, 208012521, 210275324, 210280973, 223378476, 226088031, 228660263, 242059974, 242612641, 249565832, 252160841, 252216210, 252451358, 252554234
|
| Target and Pathway |
| Target(s) |
Myosin light chain kinase, smooth muscle and non-muscle isozymes |
Target Info |
Inhibitor |
[1]
|
|---|
| mRNA of DMPK |
Target Info |
Inhibitor |
[1]
|
| p21 protein (Cdc42/Rac)-activated kinase 1 |
Target Info |
Inhibitor |
[1]
|
| CDC42 binding protein kinase alpha (DMPK-like) |
Target Info |
Inhibitor |
[1]
|
| LIM domain kinase 1 |
Target Info |
Inhibitor |
[1]
|
| protein kinase N1 |
Target Info |
Inhibitor |
[1]
|
| Rho associated protein kinase 2 |
Target Info |
Inhibitor |
[1]
|
| Rho-associated protein kinase 1 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
cGMP-PKG signaling pathway
|
|
Vascular smooth muscle contraction
|
|
Focal adhesion
|
|
Platelet activation
|
|
Regulation of actin cytoskeleton
|
|
Oxytocin signaling pathway
|
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Gastric acid secretionhsa04022:cGMP-PKG signaling pathway
|
|
cAMP signaling pathway
|
|
Chemokine signaling pathway
|
|
Sphingolipid signaling pathway
|
|
Wnt signaling pathway
|
|
Axon guidance
|
|
Leukocyte transendothelial migration
|
|
Pathogenic Escherichia coli infection
|
|
Shigellosis
|
|
Salmonella infection
|
|
Pathways in cancer
|
|
Proteoglycans in cancerhsa04022:cGMP-PKG signaling pathway
|
|
TGF-beta signaling pathway
|
|
Proteoglycans in cancer
|
|
MicroRNAs in cancer
|
|
PANTHER Pathway
|
Cytoskeletal regulation by Rho GTPase
|
|
Inflammation mediated by chemokine and cytokine signaling pathwayP00016:Cytoskeletal regulation by Rho GTPaseP00016:Cytoskeletal regulation by Rho GTPase
|
|
Inflammation mediated by chemokine and cytokine signaling pathway
|
|
CCKR signaling map ST
|
|
Pathway Interaction Database
|
Aurora B signalingrhoa_pathway:RhoA signaling pathway
|
|
Plasma membrane estrogen receptor signaling
|
|
Osteopontin-mediated events
|
|
PLK1 signaling events
|
|
PAR4-mediated thrombin signaling events
|
|
PAR1-mediated thrombin signaling events
|
|
Signaling events mediated by focal adhesion kinaseprlsignalingeventspathway:Signaling events mediated by PRL
|
|
RhoA signaling pathway
|
|
Noncanonical Wnt signaling pathway
|
|
EPHB forward signaling
|
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Thromboxane A2 receptor signaling
|
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amb2 Integrin signaling
|
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Integrins in angiogenesis
|
|
EPHA forward signaling
|
|
Stabilization and expansion of the E-cadherin adherens junction
|
|
Signaling events mediated by VEGFR1 and VEGFR2
|
|
N-cadherin signaling events
|
|
PathWhiz Pathway
|
Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
|
|
Muscle/Heart Contraction
|
|
Reactome
|
Smooth Muscle ContractionR-HSA-3928662:EPHB-mediated forward signaling
|
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EPHA-mediated growth cone collapse
|
|
G alpha (12/13) signalling events
|
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Sema4D induced cell migration and growth-cone collapse
|
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VEGFA-VEGFR2 Pathway
|
|
RHO GTPases Activate ROCKsR-HSA-111465:Apoptotic cleavage of cellular proteins
|
|
EPHB-mediated forward signaling
|
|
RHO GTPases Activate ROCKs
|
|
WikiPathways
|
Regulation of Actin Cytoskeleton
|
|
Focal Adhesion
|
|
Endothelin Pathways
|
|
Muscle contraction
|
|
MicroRNAs in cardiomyocyte hypertrophyWP524:G13 Signaling Pathway
|
|
JAK/STAT
|
|
Spinal Cord Injury
|
|
Pathogenic Escherichia coli infection
|
|
Leptin signaling pathway
|
|
Semaphorin interactions
|
|
Integrin-mediated Cell Adhesion
|
|
GPCR downstream signaling
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
|
Androgen receptor signaling pathwayWP524:G13 Signaling Pathway
|
|
EGF/EGFR Signaling Pathway
|
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TGF beta Signaling Pathway
|
|
AGE/RAGE pathway
|
|
Regulation of Microtubule Cytoskeleton
|
|
Apoptotic execution phase
|
|
Androgen receptor signaling pathway
|
| References |
| REF 1 | Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). Medchemcomm. 2012 Jun 1;3(6):699-709. Epub 2012 Jan 27. |
|---|
