Drug General Information
Drug ID	D02YMQ
Former ID	DNC006472
Drug Name	6-phenyl-3-(pyridin-4-yl)-1H-indole
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528041]
Structure		Download 2D MOL 3D MOL
Formula	C19H14N2
Canonical SMILES	C1=CC=C(C=C1)C2=CC3=C(C=C2)C(=CN3)C4=CC=NC=C4
InChI	1S/C19H14N2/c1-2-4-14(5-3-1)16-6-7-17-18(13-21-19(17)12-16)15-8-10-20-11-9-15/h1-13,21H
InChIKey	QPUYBWAAFGEKSG-UHFFFAOYSA-N
PubChem Compound ID	44410733
Target and Pathway
Target(s)	Inosine-5'-monophosphate dehydrogenase 2	Target Info	Inhibitor	[528041]
BioCyc Pathway	Purine nucleotides degradation
	Urate biosynthesis/inosine 5'-phosphate degradation
	Guanosine nucleotides de novo biosynthesis
	Superpathway of purine nucleotide salvage
	Purine nucleotides de novo biosynthesis
	Guanosine ribonucleotides de novo biosynthesis
KEGG Pathway	Purine metabolism
	Drug metabolism - other enzymes
	Metabolic pathways
PANTHER Pathway	De novo purine biosynthesis
Reactome	Purine ribonucleoside monophosphate biosynthesis
References
Ref 528041	Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42. Epub 2006 Feb 17.Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships.
Ref 528041	Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42. Epub 2006 Feb 17.Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships.

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