Drug General Information
Drug ID	D0I9KV
Former ID	DNC006226
Drug Name	1-(4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528036]
Structure		Download 2D MOL 3D MOL
Formula	C15H20BrNO
Canonical SMILES	CCCC(C(=O)C1=CC=C(C=C1)Br)N2CCCC2
InChI	1S/C15H20BrNO/c1-2-5-14(17-10-3-4-11-17)15(18)12-6-8-13(16)9-7-12/h6-9,14H,2-5,10-11H2,1H3
InChIKey	RAHKQMUBMIJUFG-UHFFFAOYSA-N
PubChem Compound ID	11220599
Target and Pathway
Target(s)	Sodium-dependent noradrenaline transporter	Target Info	Inhibitor	[528036]
	Sodium-dependent dopamine transporter	Target Info	Inhibitor	[528036]
	Sodium-dependent serotonin transporter	Target Info	Inhibitor	[528036]
KEGG Pathway	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Amphetamine addiction
	Alcoholismhsa04726:Serotonergic synapse
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Adrenaline and noradrenaline biosynthesisP00001:Adrenaline and noradrenaline biosynthesis
	Parkinson disease
	Dopamine receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
	5HT2 type receptor mediated signaling pathway
	5HT3 type receptor mediated signaling pathway
	5HT4 type receptor mediated signaling pathway
Pathway Interaction Database	Alpha-synuclein signaling
Reactome	Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways	Monoamine Transport
	NRF2 pathway
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
	Dopaminergic Neurogenesis
	Parkinsons Disease Pathway
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
	Neurotransmitter Clearance In The Synaptic CleftWP727:Monoamine Transport
	SIDS Susceptibility Pathways
	Synaptic Vesicle Pathway
	Serotonin Transporter Activity
References
Ref 528036	J Med Chem. 2006 Feb 23;49(4):1420-32.1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors.
Ref 528036	J Med Chem. 2006 Feb 23;49(4):1420-32.1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors.

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