Drug Information

Drug General Information
Drug ID
D0Q0IR
Former ID
DIB018781
Drug Name
AGN193109
Synonyms
AGN 193109; AGN-93109
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539706]
Structure
Download
2D MOL
Formula
C28H24O2
InChI
InChI=1S/C28H24O2/c1-19-4-11-22(12-5-19)24-16-17-28(2,3)26-15-10-21(18-25(24)26)7-6-20-8-13-23(14-9-20)27(29)30/h4-5,8-16,18H,17H2,1-3H3,(H,29,30)
InChIKey
NCEQLLNVRRTCKJ-UHFFFAOYSA-N
PubChem Compound ID
177238
PubChem Substance ID
7979401, 10258566, 14805325, 33500715, 50066202, 53789893, 56312170, 56312841, 57395364, 75214057, 103385975, 103938794, 104426234, 125686239, 128681227, 135154828, 135649903, 137118905, 142527919, 162253731, 163122313, 164835152, 198974156, 204380645, 223782601, 226680842
Target and Pathway
Target(s) Retinoic acid receptor gamma Target Info Antagonist [525680]
Retinoic acid receptor beta Target Info Antagonist [525680]
Retinoic acid receptor alpha Target Info Antagonist [525680]
KEGG Pathway Pathways in cancer
Small cell lung cancer
Non-small cell lung cancerhsa05200:Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Pathway Interaction Database Retinoic acid receptors-mediated signaling
Reactome Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
WikiPathways Vitamin A and Carotenoid Metabolism
Nuclear Receptors in Lipid Metabolism and Toxicity
Mesodermal Commitment Pathway
Endoderm Differentiation
Nuclear ReceptorsWP716:Vitamin A and Carotenoid Metabolism
Integrated Pancreatic Cancer Pathway
Adipogenesis
Nuclear Receptors
References
Ref 539706(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2640).
Ref 525680Therapeutic applications for ligands of retinoid receptors. Curr Pharm Des. 2000 Jan;6(1):25-58.

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