Drug General Information
Drug ID	D02FPU
Former ID	DNC011287
Drug Name	N-(1-oxobutan-2-yl)-3-(trifluoromethyl)benzamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531241]
Structure		Download 2D MOL 3D MOL
Formula	C12H12F3NO2
Canonical SMILES	CCC(C=O)NC(=O)C1=CC(=CC=C1)C(F)(F)F
InChI	1S/C12H12F3NO2/c1-2-10(7-17)16-11(18)8-4-3-5-9(6-8)12(13,14)15/h3-7,10H,2H2,1H3,(H,16,18)
InChIKey	BXZCQIXITWILKZ-UHFFFAOYSA-N
PubChem Compound ID	52945617
Target and Pathway
Target(s)	Cathepsin S	Target Info	Inhibitor	[531241]
KEGG Pathway	Lysosome
	Phagosome
	Antigen processing and presentation
	Tuberculosis
NetPath Pathway	Leptin Signaling Pathway
	IL2 Signaling Pathway
Reactome	Endosomal/Vacuolar pathway
	Degradation of the extracellular matrix
	Trafficking and processing of endosomal TLR
	Assembly of collagen fibrils and other multimeric structures
	MHC class II antigen presentation
WikiPathways	Class I MHC mediated antigen processing & presentation
	Trafficking and processing of endosomal TLR
References
Ref 531241	Bioorg Med Chem Lett. 2010 Dec 1;20(23):6890-4. Epub 2010 Oct 26.Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors.
Ref 531241	Bioorg Med Chem Lett. 2010 Dec 1;20(23):6890-4. Epub 2010 Oct 26.Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors.

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