Drug Information

Drug General Information
Drug ID
D0OJ4L
Former ID
DAP000878
Drug Name
Hydroxychloroquine
Synonyms
HCQ; Hidroxicloroquina; Hydroxychlorochin; Hydroxychloroguine; Hydroxychloroquinum; Idrossiclorochina; Oxichlorochinum; Oxichloroquine; Oxychlorochin; Oxychloroquine; Polirreumin; Quensyl; Idrossiclorochina [DCIT]; WIN 1258; Gen-Hydroxychloroquine 200mg Tablets; Hidroxicloroquina [INN-Spanish]; Hydroxychloroquine (INN);Hydroxychloroquine [INN:BAN]; Hydroxychloroquinum [INN-Latin]; Plaquenil (TN); Polirreumin (TN); Hydroxychloroquine Sulfate (1:1) Salt; 2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol; 2-(N-(4-(7-Chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol; 2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol; 2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol; 7-Chloro-4-(4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino)quinoline; 7-Chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline; 7-Chloro-4-(5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl)aminoquinoline
Drug Type
Small molecular drug
Indication Malaria [ICD10:B54] Approved [536651], [542210]
Therapeutic Class
Antimalarials
Company
Concordia Pharmaceuticals Inc
Structure
Download
2D MOL

3D MOL
Formula
C18H26ClN3O
InChI
InChI=1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21)
InChIKey
XXSMGPRMXLTPCZ-UHFFFAOYSA-N
CAS Number
CAS 118-42-3
PubChem Compound ID
3652
PubChem Substance ID
9255, 597669, 3140459, 5137975, 7979547, 8150104, 8152307, 10505161, 11336117, 11361356, 11462328, 11484852, 11489054, 14777730, 29215442, 29222777, 46508459, 47662363, 47885484, 48416094, 49967663, 57321921, 75004190, 85286187, 96024743, 99302030, 103566848, 104304133, 118262645, 124573764, 126687853, 129756062, 134338155, 134973873, 135702786, 136890426, 137083308, 143201344, 143401603, 160964848, 162180925, 163835395, 163836798, 165716210, 172829147, 174006176, 175607648, 177748295, 178103773, 179039315
SuperDrug ATC ID
P01BA02
SuperDrug CAS ID
cas=000118423
Target and Pathway
Target(s) Toll-like receptor 7 Target Info Antagonist [536605]
KEGG Pathway Toll-like receptor signaling pathway
Measles
Influenza A
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathway
Reactome Trafficking and processing of endosomal TLR
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
WikiPathways Toll-like receptor signaling pathway
Toll-Like Receptors Cascades
MyD88 dependent cascade initiated on endosome
Trafficking and processing of endosomal TLR
Regulation of toll-like receptor signaling pathway
References
Ref 536651Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96.
Ref 542210(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7198).
Ref 536605TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders. Inflamm Allergy Drug Targets. 2007 Dec;6(4):223-35.

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