| Drug General Information |
| Drug ID |
D0P7RO
|
| Former ID |
DNC002915
|
| Drug Name |
TRIAZOLOPYRIMIDINE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C4H3N5
|
| Canonical SMILES |
C1=NC=NC2=NNN=C21
|
| InChI |
1S/C4H3N5/c1-3-4(6-2-5-1)8-9-7-3/h1-2H,(H,5,6,7,8,9)
|
| InChIKey |
GIIGHSIIKVOWKZ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
16608254, 36724245, 43121817, 46302757, 50140638, 53788747, 57315209, 104332504, 125748763, 127319289, 127319290, 127319291, 127319292, 127319293, 127319294, 127319295, 127319296, 127319297, 127329167, 127329168, 127341707, 127345954, 127345955, 127958146, 132655354, 135021803, 135772448, 135791331, 135912883, 136300513, 137011532, 141829505, 162280987, 162495669, 162735849, 163299948, 163299951, 163299952, 172831729, 172898404, 179681510, 224297145, 226414417, 236255385, 241056617, 245146148, 251878898
|
| Target and Pathway |
| Target(s) |
Cell division protein kinase 2 |
Target Info |
Inhibitor |
[1]
|
|---|
|
KEGG Pathway
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FoxO signaling pathway
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Cell cycle
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Oocyte meiosis
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p53 signaling pathway
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PI3K-Akt signaling pathway
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Progesterone-mediated oocyte maturation
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Hepatitis B
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Measles
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Herpes simplex infection
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Epstein-Barr virus infection
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Pathways in cancer
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Viral carcinogenesis
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Prostate cancer
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Small cell lung cancer
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
|
p53 pathway
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|
p53 pathway feedback loops 2
|
|
Pathway Interaction Database
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Regulation of nuclear SMAD2/3 signaling
|
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Signaling events mediated by PRL
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p73 transcription factor network
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E2F transcription factor network
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ATR signaling pathway
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mTOR signaling pathway
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IL2-mediated signaling events
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FoxO family signaling
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FOXM1 transcription factor network
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BARD1 signaling events
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p53 pathway
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Regulation of retinoblastoma protein
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Reactome
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G0 and Early G1
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Activation of ATR in response to replication stress
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Regulation of APC/C activators between G1/S and early anaphase
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SCF(Skp2)-mediated degradation of p27/p21
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Senescence-Associated Secretory Phenotype (SASP)
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DNA Damage/Telomere Stress Induced Senescence
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Processing of DNA double-strand break ends
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G2 Phase
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Orc1 removal from chromatin
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Cyclin E associated events during G1/S transition
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Cyclin A/B1 associated events during G2/M transition
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p53-Dependent G1 DNA Damage Response
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Cyclin A:Cdk2-associated events at S phase entry
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Meiotic recombination
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Factors involved in megakaryocyte development and platelet production
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WikiPathways
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DNA Damage Response
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ID signaling pathway
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DNA Replication
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G1 to S cell cycle control
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M/G1 Transition
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S Phase
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Meiotic Recombination
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Aryl Hydrocarbon Receptor
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ATM Signaling Pathway
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Retinoblastoma (RB) in Cancer
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Spinal Cord Injury
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Integrated Pancreatic Cancer Pathway
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Oncostatin M Signaling Pathway
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Prostate Cancer
|
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Signaling Pathways in Glioblastoma
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TSH signaling pathway
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Integrated Breast Cancer Pathway
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Integrated Cancer pathway
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Synthesis of DNA
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Regulation of DNA replication
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Mitotic G2-G2/M phases
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Mitotic G1-G1/S phases
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Factors involved in megakaryocyte development and platelet production
|
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Cell Cycle
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APC/C-mediated degradation of cell cycle proteins
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Cell Cycle Checkpoints
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miRNA Regulation of DNA Damage Response
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| References |
| REF 1 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. |
|---|
