Drug Information

Drug General Information
Drug ID
D05ZWG
Former ID
DNC001320
Drug Name
Senktide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533307], [539349]
Structure
Download
2D MOL

3D MOL
Formula
C40H55N7O11S
InChI
InChI=1S/C40H55N7O11S/c1-24(2)19-28(37(55)45-27(36(41)54)17-18-59-4)44-33(49)23-42-39(57)31(21-26-13-9-6-10-14-26)47(3)40(58)30(20-25-11-7-5-8-12-25)46-38(56)29(22-35(52)53)43-32(48)15-16-34(50)51/h5-14,24,27-31H,15-23H2,1-4H3,(H2,41,54)(H,42,57)(H,43,48)(H,44,49)(H,45,55)(H,46,56)(H,50,51)(H,52,53)/t27-,28-,29-,30-,31-/m0/s1
InChIKey
HMHYXLVEFVGOPM-QKUYTOGTSA-N
CAS Number
CAS 189261-10-7
PubChem Compound ID
108147
PubChem Substance ID
10234616, 14791601, 14914006, 44437035, 49997175, 51268855, 57338465, 103328188, 103949376, 104231759, 104380618, 135064975, 135652459, 144240098, 163124004, 204360404, 231090555
Target and Pathway
Target(s) Nigral tachykinin NK(3) receptor Target Info Agonist [535700], [537952]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 533307Ovarian and hormonal responses to single or continuous peripheral administration of senktide, a neurokinin 3 receptor agonist, during the follicular phase in goats. Domest Anim Endocrinol. 2015 Oct;53:136-43.
Ref 539349(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2127).
Ref 535700Implication of nigral tachykinin NK3 receptors in the maintenance of hypertension in spontaneously hypertensive rats: a pharmacologic and autoradiographic study. Br J Pharmacol. 2003 Feb;138(4):554-63.
Ref 537952Neurokinin-3 receptors modulate dopamine cell function and alter the effects of 6-hydroxydopamine. Brain Res. 1995 Oct 9;695(1):19-24.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.