Drug Information

Drug General Information
Drug ID
D0XB3U
Former ID
DNC006660
Drug Name
BM-573
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528239]
Structure
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2D MOL

3D MOL
Formula
C18H22N4O5S
Canonical SMILES
B(C1=C(N=C(C=C1)Cl)Cl)(O)O
InChI
1S/C5H4BCl2NO2/c7-4-2-1-3(6(10)11)5(8)9-4/h1-2,10-11H
InChIKey
XBBLBQZAVMHEER-UHFFFAOYSA-N
PubChem Compound ID
5312142
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Inhibitor [528239]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 528239J Med Chem. 2006 Jun 15;49(12):3701-9.Synthesis and pharmacological evaluation of novel nitrobenzenic thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor.
Ref 528239J Med Chem. 2006 Jun 15;49(12):3701-9.Synthesis and pharmacological evaluation of novel nitrobenzenic thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor.

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