Drug General Information
Drug ID	D00FGA
Former ID	DNC004972
Drug Name	Pyrrolidine-1-carbonitrile
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527556]
Structure		Download 2D MOL 3D MOL
Formula	C5H8N2
Canonical SMILES	C1CCN(C1)C#N
InChI	1S/C5H8N2/c6-5-7-3-1-2-4-7/h1-4H2
InChIKey	QJRYYOWARFCJQZ-UHFFFAOYSA-N
PubChem Compound ID	73737
Target and Pathway
Target(s)	Cathepsin K	Target Info	Inhibitor	[527556]
KEGG Pathway	Lysosome
	Osteoclast differentiation
	Toll-like receptor signaling pathway
	Rheumatoid arthritis
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
	RANKL Signaling Pathway
	IL2 Signaling Pathway
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
	Trafficking and processing of endosomal TLR
	MHC class II antigen presentation
WikiPathways	RANKL/RANK Signaling Pathway
	Osteoclast Signaling
References
Ref 527556	Bioorg Med Chem Lett. 2005 Jun 15;15(12):3039-43.Acyclic cyanamide-based inhibitors of cathepsin K.
Ref 527556	Bioorg Med Chem Lett. 2005 Jun 15;15(12):3039-43.Acyclic cyanamide-based inhibitors of cathepsin K.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.