Drug Information

Drug General Information
Drug ID
D09FRL
Former ID
DIB020659
Drug Name
PD123177
Synonyms
PD 123177; PD-123177
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541239]
Structure
Download
2D MOL
Formula
C29H28N4O3
InChI
InChI=1S/C29H28N4O3/c1-19-14-20(12-13-23(19)30)16-32-18-31-24-17-33(26(29(35)36)15-25(24)32)28(34)27(21-8-4-2-5-9-21)22-10-6-3-7-11-22/h2-14,18,26-27H,15-17,30H2,1H3,(H,35,36)
InChIKey
KLVDUSUYBDMJKR-UHFFFAOYSA-N
PubChem Compound ID
114899
PubChem Substance ID
10236543, 14785640, 17396544, 29296503, 47285831, 47510026, 47583708, 47657080, 47954437, 57338876, 76684264, 85209225, 104397130, 128400921, 135071376, 135650791, 137230989, 160849507, 179293544, 223445148, 232718785, 242099790
Target and Pathway
Target(s) Type-2 angiotensin II receptor Target Info Antagonist [532113]
KEGG Pathway Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Renin-angiotensin system
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways ACE Inhibitor Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 541239(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 596).
Ref 532113Two distinct angiotensin II receptor binding sites in rat adrenal revealed by new selective nonpeptide ligands. Mol Pharmacol. 1990 Mar;37(3):347-51.

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