Drug Information

Drug General Information
Drug ID
D08GMO
Former ID
DNC009392
Drug Name
3-(4-aminophenyl)quinoxaline-5-carboxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529901]
Structure
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2D MOL

3D MOL
Formula
C15H12N4O
Canonical SMILES
C1=CC(=C2C(=C1)N=CC(=N2)C3=CC=C(C=C3)N)C(=O)N
InChI
1S/C15H12N4O/c16-10-6-4-9(5-7-10)13-8-18-12-3-1-2-11(15(17)20)14(12)19-13/h1-8H,16H2,(H2,17,20)
InChIKey
JCXJUCVUESBKLT-UHFFFAOYSA-N
PubChem Compound ID
25218519
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [529901]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 529901J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors.
Ref 529901J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors.

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