Drug Information
Drug General Information | |||||
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Drug ID |
D0AY5T
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Former ID |
DIB021189
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Drug Name |
VU0400195
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Synonyms |
ML182
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [541402] | ||
Structure |
Download2D MOL |
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Formula |
C21H16ClN3O3
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InChI |
InChI=1S/C21H16ClN3O3/c22-14-10-13(24-19(26)15-3-1-2-8-23-15)6-7-16(14)25-20(27)17-11-4-5-12(9-11)18(17)21(25)28/h1-8,10-12,17-18H,9H2,(H,24,26)/t11-,12+,17-,18?/m1/s1
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InChIKey |
LJUABYFUJVRUSJ-KNGMQDLYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Metabotropic glutamate receptor 4 | Target Info | Modulator (allosteric modulator) | [531644] | |
References | |||||
Ref 531644 | Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal model. J Med Chem. 2011 Nov 10;54(21):7639-47. |
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