Drug Information

Drug General Information
Drug ID
D0S6JG
Former ID
DAP000082
Drug Name
Liothyronine
Synonyms
Liothyronin; Liothyroninum; Liotironina; Lyothyronine; Rathyronine; Tresitope; Triiodothyronine; Triothyrone; THYROID HORMONE; Liothyronine I 131; Liothyronine I 131 [USAN]; T3 liothyronine; Cytomel (TN); Euthroid-1; Euthroid-2; Euthroid-3; L-Liothyronine; L-T3; Liothyronine (INN); Liothyronine [INN:BAN]; Liothyroninum[INN-Latin]; Liotironina [INN-Spanish]; T3 (Hormone); T3 (Triiodothyronine); T3 (VAN); T3 (amino acid); Tertroxin (TN); Thyrolar-1; Thyrolar-2; Thyrolar-3; Tri-Thyrotope; Triiodothyronine (T3); Triomet-131; Euthroid-0.5; Thyrolar-0.25; Thyrolar-0.5; Triiodo-L-thyronine; L-3,3',5-TriioDOThyronine; L-3,5,3'-Triiodothyronine; TRIIODOTHYRONINE (T3 OR LIOTHYRONINE, ACTIVE) (6-11%); Thyronine, 3,3',5-triiodo-, L-(6CI); O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine; L-3-(4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl)alanine; L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-(9CI); (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid; 3,3',5-Triiodo-L-thyronine; 3,3',5-Triiodothyronine; 3,3'5-Triiodo-L-thyronine; 3,5,3'-Tri-iodo-L-thyronine; 3,5,3'-Triiodo-L-thyronine; 3,5,3'-triiodothyronine; 3,5,3'TRIIODOTHYRONINE; 4-(3-Iodo-4-hydroxyphenoxy)-3,5-diiodophenylalanine; 4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenylalanine; 4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine
Drug Type
Small molecular drug
Indication Hypothyroidism of any etiology [ICD10:R68, T68] Approved [551871]
Therapeutic Class
Hormone Replacement Agents
Company
King Pharmaceuticals, Inc
Structure
Download
2D MOL

3D MOL
Formula
C15H12I3NO4
InChI
InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
InChIKey
AUYYCJSJGJYCDS-LBPRGKRZSA-N
CAS Number
CAS 6893-02-3
PubChem Compound ID
5920
PubChem Substance ID
5481, 830311, 832593, 854428, 4253003, 7890655, 7980832, 8002138, 8145172, 8153668, 10321236, 11364339, 11364976, 11366901, 11367538, 11369463, 11370100, 11372994, 11373139, 11373810, 11375700, 11377625, 11378271, 11457873, 11466881, 11468001, 11485903, 11486522, 11489800, 11491702, 11492141, 11495259, 11532858, 14710501, 14710502, 14936961, 14964754, 24900088, 26737095, 26737097, 26753840, 29224945, 46393605, 46506352, 46518913, 47217059, 47291379, 47440547, 47440548, 47885656
ChEBI ID
ChEBI:18258
SuperDrug ATC ID
H03AA02
SuperDrug CAS ID
cas=000055061
Target and Pathway
Target(s) Thyroid hormone receptor alpha Target Info Antagonist [536362], [536494]
KEGG Pathway Neuroactive ligand-receptor interaction
Thyroid hormone signaling pathway
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptor
Reactome Nuclear Receptor transcription pathway
WikiPathways Endochondral Ossification
Nuclear Receptors
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536362Thyroid hormone receptors in brain development and function. Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):249-59.
Ref 536494Evaluation of thyroid hormone action in a case of generalized resistance to thyroid hormone with chronic thyroiditis: discovery of a novel heterozygous missense mutation (G347A). Endocr J. 2007 Dec;54(5):727-32. Epub 2007 Sep 7.

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