Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09TJK
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| Former ID |
DNC007238
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| Drug Name |
3-(6-morpholino-4-oxo-4H-pyran-2-yl)benzonitrile
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [528738] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C16H14N2O3
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| Canonical SMILES |
C1COCCN1C2=CC(=O)C=C(O2)C3=CC=CC(=C3)C#N
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| InChI |
1S/C16H14N2O3/c17-11-12-2-1-3-13(8-12)15-9-14(19)10-16(21-15)18-4-6-20-7-5-18/h1-3,8-10H,4-7H2
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| InChIKey |
IBXUISQIAHYEGD-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | DNA-dependent protein kinase catalytic subunit | Target Info | Inhibitor | [528738] | |
| KEGG Pathway | Non-homologous end-joining | ||||
| Cell cycle | |||||
| NetPath Pathway | IL1 Signaling Pathway | ||||
| Reactome | Nonhomologous End-Joining (NHEJ) | ||||
| References | |||||
| Ref 528738 | J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase. | ||||
| Ref 528738 | J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase. | ||||
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