Drug General Information
Drug ID	D05AIT
Former ID	DNC010817
Drug Name	3-[6-(5-Chloro-2-thienyl)pyridin-2-yl]phenol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530868]
Structure		Download 2D MOL 3D MOL
Formula	C15H10ClNOS
Canonical SMILES	C1=CC(=CC(=C1)O)C2=NC(=CC=C2)C3=CC=C(S3)Cl
InChI	1S/C15H10ClNOS/c16-15-8-7-14(19-15)13-6-2-5-12(17-13)10-3-1-4-11(18)9-10/h1-9,18H
InChIKey	IYXPXDBFKHBESO-UHFFFAOYSA-N
PubChem Compound ID	46887580
Target and Pathway
Target(s)	Estradiol 17 beta-dehydrogenase 1	Target Info	Inhibitor	[530868]
BioCyc Pathway	Superpathway of steroid hormone biosynthesis
	Estradiol biosynthesis I
KEGG Pathway	Steroid hormone biosynthesis
	Metabolic pathways
	Ovarian steroidogenesis
NetPath Pathway	FSH Signaling Pathway
PANTHER Pathway	Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway	Androgen and Estrogen Metabolism
Reactome	The canonical retinoid cycle in rods (twilight vision)
WikiPathways	Steroid Biosynthesis
	Metabolism of steroid hormones and vitamin D
	Prostate Cancer
References
Ref 530868	Bioorg Med Chem. 2010 May 15;18(10):3494-505. Epub 2010 Mar 29.Novel estrone mimetics with high 17beta-HSD1 inhibitory activity.
Ref 530868	Bioorg Med Chem. 2010 May 15;18(10):3494-505. Epub 2010 Mar 29.Novel estrone mimetics with high 17beta-HSD1 inhibitory activity.

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