Drug Information

Drug General Information
Drug ID
DXA6CG
Drug Name
Sodium; 3-[3-hydroxycarbamoyl-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl]-propionate
Synonyms
CHEMBL343392
Indication Discovery agent Investigative [1587926]
Formula
C21H22N3O8S.Na
Canonical SMILES
[Na+].COc1ccc(cc1)S(=O)(=O)N2Cc3cc(NC(=O)CCC(=O)[O-])ccc3CC2C(=O)NO
InChI
InChI=1S/C21H23N3O8S.Na/c1-32-16-4-6-17(7-5-16)33(30,31)24-12-14-10-15(22-19(25)8-9-20(26)27)3-2-13(14)11-18(24)21(28)23-29;/h2-7,10,18,29H,8-9,11-12H2,1H3,(H,22,25)(H,23,28)(H,26,27);/q;+1/p-1
InChIKey
CWDNVRNHSFACNA-UHFFFAOYSA-M
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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