Drug Information

Drug General Information
Drug ID
DXD2MH
Drug Name
Oxo-[2-(5-pyridin-2-yl-thiophene-2-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-acetic acid
Synonyms
CHEMBL138181
Indication Discovery agent Investigative [1587926]
Formula
C20H16N2O5S2
Canonical SMILES
OC(=O)C(=O)C1Cc2ccccc2CN1S(=O)(=O)c3ccc(s3)c4ccccn4
InChI
InChI=1S/C20H16N2O5S2/c23-19(20(24)25)16-11-13-5-1-2-6-14(13)12-22(16)29(26,27)18-9-8-17(28-18)15-7-3-4-10-21-15/h1-10,16H,11-12H2,(H,24,25)
InChIKey
YXXPZIJDDIJKDH-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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