Drug Information

Drug General Information
Drug ID
DX4CEE
Drug Name
N-{4-[1-[2-(4-Morpholinyl)-2-oxoethyl]-4-(1H-pyrrolo[2,3-b]-pyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-N'-phenylurea
Synonyms
CHEMBL1094507
Indication Discovery agent Investigative [1587926]
Formula
C29H27N7O3
Canonical SMILES
O=C(Nc1ccccc1)Nc2ccc(cc2)c3nn(CC(=O)N4CCOCC4)cc3c5ccnc6[nH]ccc56
InChI
InChI=1S/C29H27N7O3/c37-26(35-14-16-39-17-15-35)19-36-18-25(23-10-12-30-28-24(23)11-13-31-28)27(34-36)20-6-8-22(9-7-20)33-29(38)32-21-4-2-1-3-5-21/h1-13,18H,14-17,19H2,(H,30,31)(H2,32,33,38)
InChIKey
RHDBNLYQAOUIAE-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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