Drug Information

Drug General Information
Drug ID
DXH6YA
Drug Name
N-[3-[(3-Fluoro-1-azetidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Trifluoroacetate
Synonyms
CHEMBL1650547
Indication Discovery agent Investigative [1587926]
Formula
C19H18F4N8O2S
Canonical SMILES
Cc1cn2c(cnc2c(Nc3cc(CN4CC(F)C4)ns3)n1)c5cn[nH]c5.OC(=O)C(F)(F)F
InChI
InChI=1S/C17H17FN8S.C2HF3O2/c1-10-6-26-14(11-3-20-21-4-11)5-19-17(26)16(22-10)23-15-2-13(24-27-15)9-25-7-12(18)8-25;3-2(4,5)1(6)7/h2-6,12H,7-9H2,1H3,(H,20,21)(H,22,23);(H,6,7)
InChIKey
CQCUVFFLJGJLSK-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.