Drug Information

Drug General Information
Drug ID
DXO5QV
Drug Name
N*7*-(4-Diethylamino-butyl)-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridine-2,7-diamine
Synonyms
CHEMBL188978
Indication Discovery agent Investigative [1587926]
Formula
C24H33N5O2
Canonical SMILES
CCN(CC)CCCCNc1cc2nc(N)c(cc2cn1)c3cc(OC)cc(OC)c3
InChI
InChI=1S/C24H33N5O2/c1-5-29(6-2)10-8-7-9-26-23-15-22-18(16-27-23)13-21(24(25)28-22)17-11-19(30-3)14-20(12-17)31-4/h11-16H,5-10H2,1-4H3,(H2,25,28)(H,26,27)
InChIKey
CWWGWUITOJWIQB-UHFFFAOYSA-N
Target and Pathway
Target(s) Basic fibroblast growth factor receptor 1 Target Info [1587926]
Vascular endothelial growth factor receptor 2 Target Info [1587926]
Vascular endothelial growth factor receptor 2 Target Info [1587926]
Basic fibroblast growth factor receptor 1 Target Info [1587926]
KEGG Pathway MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Adherens junction
Signaling pathways regulating pluripotency of stem cells
Regulation of actin cytoskeleton
Pathways in cancer
Proteoglycans in cancer
Prostate cancer
Melanoma
Central carbon metabolism in cancerhsa04014:Ras signaling pathway
Cytokine-cytokine receptor interaction
Endocytosis
VEGF signaling pathway
Focal adhesion
NetPath Pathway TCR Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Angiogenesis
FGF signaling pathwayP00005:Angiogenesis
VEGF signaling pathway
Pathway Interaction Database Glypican 1 network
Syndecan-4-mediated signaling events
N-cadherin signaling events
FGF signaling pathwayhif2pathway:HIF-2-alpha transcription factor network
Beta3 integrin cell surface interactions
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
VEGF and VEGFR signaling network
Integrins in angiogenesis
Signaling events mediated by VEGFR1 and VEGFR2
Notch-mediated HES/HEY network
Reactome Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
EPHA-mediated growth cone collapse
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
WikiPathways Regulation of Actin Cytoskeleton
Endochondral Ossification
MAPK Signaling Pathway
Mesodermal Commitment Pathway
Hair Follicle Development: Induction (Part 1 of 3)
Integrated Pancreatic Cancer Pathway
Signaling Pathways in Glioblastoma
Neural Crest Differentiation
Signaling by FGFRWP306:Focal Adhesion
Nifedipine Activity
Cardiac Progenitor Differentiation
Signaling by VEGF
Angiogenesis
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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