Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXE3XQ
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| Drug Name |
N-(5-(4-((2-fluoro-5-(trifluoromethyl)-phenyl)aminocarbonylamino)phenoxy)-1H-benzimidazol-2-yl)-acetamide
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| Synonyms |
CHEMBL243916
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C23H17F4N5O3
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| Canonical SMILES |
CC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1
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| InChI |
InChI=1S/C23H17F4N5O3/c1-12(33)28-21-30-18-9-7-16(11-20(18)31-21)35-15-5-3-14(4-6-15)29-22(34)32-19-10-13(23(25,26)27)2-8-17(19)24/h2-11H,1H3,(H2,29,32,34)(H2,28,30,31,33)
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| InChIKey |
PSQQJYVAJZSKPM-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Angiopoietin 1 receptor | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathwayP00005:Angiogenesis | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling | |||||
| References | |||||
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