Drug Information

Drug General Information
Drug ID
DX5DNB
Drug Name
N-(4-{1-Ethyl-4-[2-({[2-(methylsulfonyl)ethyl]amino}methyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyrazol-3-yl}phenyl)-N'-phenylurea
Synonyms
CHEMBL1096492
Indication Discovery agent Investigative [1587926]
Formula
C29H31N7O3S
Canonical SMILES
CCn1cc(c2ccnc3[nH]c(CNCCS(=O)(=O)C)cc23)c(n1)c4ccc(NC(=O)Nc5ccccc5)cc4
InChI
InChI=1S/C29H31N7O3S/c1-3-36-19-26(24-13-14-31-28-25(24)17-23(32-28)18-30-15-16-40(2,38)39)27(35-36)20-9-11-22(12-10-20)34-29(37)33-21-7-5-4-6-8-21/h4-14,17,19,30H,3,15-16,18H2,1-2H3,(H,31,32)(H2,33,34,37)
InChIKey
KEZAFIAURWAGLZ-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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