Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXMK2R
|
||||
| Drug Name |
N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-methyl-5-((5-(pyrrolidin-1-ylmethyl)thiophen-2-yl)ethynyl)pyrimidin-4-amine
|
||||
| Synonyms |
CHEMBL1934628
|
||||
| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C29H26ClFN4OS
|
||||
| Canonical SMILES |
Cc1ncnc(Nc2ccc(OCc3cccc(F)c3)c(Cl)c2)c1C#Cc4ccc(CN5CCCC5)s4
|
||||
| InChI |
InChI=1S/C29H26ClFN4OS/c1-20-26(11-10-24-8-9-25(37-24)17-35-13-2-3-14-35)29(33-19-32-20)34-23-7-12-28(27(30)16-23)36-18-21-5-4-6-22(31)15-21/h4-9,12,15-16,19H,2-3,13-14,17-18H2,1H3,(H,32,33,34)
|
||||
| InChIKey |
HEBKNWWRCIXZSC-UHFFFAOYSA-N
|
||||
| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.