Drug Information

Drug General Information
Drug ID
DXK8OX
Drug Name
Carbonic acid ethyl ester 3-hydroxycarbamoyl-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-7-yl ester
Synonyms
CHEMBL341604
Indication Discovery agent Investigative [1587926]
Formula
C20H22N2O8S
Canonical SMILES
CCOC(=O)Oc1ccc2CC(N(Cc2c1)S(=O)(=O)c3ccc(OC)cc3)C(=O)NO
InChI
InChI=1S/C20H22N2O8S/c1-3-29-20(24)30-16-5-4-13-11-18(19(23)21-25)22(12-14(13)10-16)31(26,27)17-8-6-15(28-2)7-9-17/h4-10,18,25H,3,11-12H2,1-2H3,(H,21,23)
InChIKey
VZEDRBAGPXKVHL-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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