| Drug General Information |
| Drug ID |
DX4NUN
|
| Drug Name |
5-[1-(3-Fluoro-phenyl)-meth-(Z)-ylidene]-2,2,4-trimethyl-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one
|
| Synonyms |
CHEMBL34824
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Formula |
C26H22FNO2
|
| Canonical SMILES |
CC1C(=O)C(C)(C)Nc2ccc3c4ccccc4O\\C(=C/c5cccc(F)c5)\\c3c12
|
| InChI |
InChI=1S/C26H22FNO2/c1-15-23-20(28-26(2,3)25(15)29)12-11-19-18-9-4-5-10-21(18)30-22(24(19)23)14-16-7-6-8-17(27)13-16/h4-15,28H,1-3H3/b22-14-
|
| InChIKey |
RUEYZSNXUIKMJQ-HMAPJEAMSA-N
|
| Target and Pathway |
| Target(s) |
Progesterone receptor |
Target Info |
|
[1]
|
|---|
| mRNA of androgen receptor |
Target Info |
|
[1]
|
|
KEGG Pathway
|
Oocyte meiosis
|
|
Progesterone-mediated oocyte maturationhsa04114:Oocyte meiosis
|
|
Pathways in cancer
|
|
Prostate cancer
|
|
NetPath Pathway
|
EGFR1 Signaling Pathway
|
|
AndrogenReceptor Signaling Pathway
|
|
FSH Signaling Pathway
|
|
Pathway Interaction Database
|
Cellular roles of Anthrax toxinsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
|
|
Coregulation of Androgen receptor activity
|
|
Regulation of Androgen receptor activity
|
|
Nongenotropic Androgen signaling
|
|
Regulation of nuclear beta catenin signaling and target gene transcription
|
|
FOXA1 transcription factor network
|
|
Notch-mediated HES/HEY network
|
|
Reactome
|
Nuclear signaling by ERBB4
|
|
Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
|
|
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
|
|
WikiPathways
|
Ovarian Infertility Genes
|
|
Signaling by ERBB4
|
|
Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
|
|
Integrated Pancreatic Cancer Pathway
|
|
Prostate Cancer
|
|
Integrated Breast Cancer Pathway
|
|
Nuclear Receptors
|
|
Androgen receptor signaling pathway
|
| References |
| REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 |
|---|
