Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX2ATX
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| Drug Name |
4-azido-N-(2-(2-(4-(4-chloro-2-fluorophenylamino)-6-methoxyquinazolin-7-yloxy)ethoxy)ethyl)-2,3,5,6-tetrafluorobenzamide
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| Synonyms |
CHEMBL199573
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C26H19ClF5N7O4
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| Canonical SMILES |
COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCOCCNC(=O)c4c(F)c(F)c(N=[N+]=[N-])c(F)c4F
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| InChI |
InChI=1S/C26H19ClF5N7O4/c1-41-17-9-13-16(35-11-36-25(13)37-15-3-2-12(27)8-14(15)28)10-18(17)43-7-6-42-5-4-34-26(40)19-20(29)22(31)24(38-39-33)23(32)21(19)30/h2-3,8-11H,4-7H2,1H3,(H,34,40)(H,35,36,37)
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| InChIKey |
SPKLCZINGKURTD-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Vascular endothelial growth factor receptor 1 | Target Info | [1587926] | |||
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| Cytokine-cytokine receptor interaction | |||||
| Endocytosis | |||||
| PI3K-Akt signaling pathway | |||||
| VEGF signaling pathway | |||||
| Focal adhesion | |||||
| Proteoglycans in cancerhsa04014:Ras signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Transcriptional misregulation in cancer | |||||
| Rheumatoid arthritis | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathway | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkglypican_1pathway:Glypican 1 network | |||||
| S1P3 pathway | |||||
| VEGFR1 specific signals | |||||
| References | |||||
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