Drug Information

Drug General Information
Drug ID
DXR3CW
Drug Name
4-[3-(4-N-Phenylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(N-pyrrolidinylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine
Synonyms
CHEMBL1099349
Indication Discovery agent Investigative [1587926]
Formula
C36H35N7O
Canonical SMILES
CCn1cc(c2ccnc3[nH]c(cc23)c4cccc(CN5CCCC5)c4)c(n1)c6ccc(NC(=O)Nc7ccccc7)cc6
InChI
InChI=1S/C36H35N7O/c1-2-43-24-32(34(41-43)26-13-15-29(16-14-26)39-36(44)38-28-11-4-3-5-12-28)30-17-18-37-35-31(30)22-33(40-35)27-10-8-9-25(21-27)23-42-19-6-7-20-42/h3-5,8-18,21-22,24H,2,6-7,19-20,23H2,1H3,(H,37,40)(H2,38,39,44)
InChIKey
LHPRXXKFQZEGMG-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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