Drug Information

Drug General Information
Drug ID
DXD0ZE
Drug Name
4-[(4-Hydroxyphenyl)methyl]-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone
Synonyms
CHEMBL1767138
Indication Discovery agent Investigative [1587926]
Formula
C21H23N3O2
Canonical SMILES
CN1CCC[C@@H]1CN2N=C(Cc3ccc(O)cc3)c4ccccc4C2=O
InChI
InChI=1S/C21H23N3O2/c1-23-12-4-5-16(23)14-24-21(26)19-7-3-2-6-18(19)20(22-24)13-15-8-10-17(25)11-9-15/h2-3,6-11,16,25H,4-5,12-14H2,1H3/t16-/m1/s1
InChIKey
UJMUXUJLIHKBEA-MRXNPFEDSA-N
Target and Pathway
Target(s) Alpha-1 adrenergic receptor Target Info [1587926]
Histamine H1 receptor Target Info [1587926]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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