Drug Information

Drug General Information
Drug ID
DXM9GA
Drug Name
3-methyl-5-(4-methyl-3-(3-((4-methylpiperazin-1-yl)methyl)styryl)-1H-indazol-5-yl)aniline
Synonyms
CHEMBL1093821
Indication Discovery agent Investigative [1587926]
Formula
C29H33N5
Canonical SMILES
CN1CCN(Cc2cccc(\\C=C\\c3n[nH]c4ccc(c(C)c34)c5cc(C)cc(N)c5)c2)CC1
InChI
InChI=1S/C29H33N5/c1-20-15-24(18-25(30)16-20)26-8-10-28-29(21(26)2)27(31-32-28)9-7-22-5-4-6-23(17-22)19-34-13-11-33(3)12-14-34/h4-10,15-18H,11-14,19,30H2,1-3H3,(H,31,32)/b9-7+
InChIKey
FMMQGWSMYANLDD-VQHVLOKHSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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