Drug General Information
Drug ID
DX5GLK
Drug Name
3-(4-(4-nitrophenyl)piperazin-1-yl)-1-phenylpropan-1-ol
Synonyms
CHEMBL137178
Indication Discovery agent Investigative [1587926]
Formula
C19H23N3O3
Canonical SMILES
OC(CCN1CCN(CC1)c2ccc(cc2)[N+](=O)[O-])c3ccccc3
InChI
InChI=1S/C19H23N3O3/c23-19(16-4-2-1-3-5-16)10-11-20-12-14-21(15-13-20)17-6-8-18(9-7-17)22(24)25/h1-9,19,23H,10-15H2
InChIKey
DCVWTZSLJPJYFB-UHFFFAOYSA-N
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info [1587926]
Sodium-dependent serotonin transporter Target Info [1587926]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04726:Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP727:Monoamine Transport
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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