Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXIG8I
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| Drug Name |
3-(2-(2-aminopyrimidin-5-yl)ethynyl)-N-(2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl)benzamide
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| Synonyms |
CHEMBL376475
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C25H22F4N6O
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| Canonical SMILES |
CN1CCN(CC1)c2ccc(cc2NC(=O)c3cc(ccc3F)C#Cc4cnc(N)nc4)C(F)(F)F
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| InChI |
InChI=1S/C25H22F4N6O/c1-34-8-10-35(11-9-34)22-7-5-18(25(27,28)29)13-21(22)33-23(36)19-12-16(4-6-20(19)26)2-3-17-14-31-24(30)32-15-17/h4-7,12-15H,8-11H2,1H3,(H,33,36)(H2,30,31,32)
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| InChIKey |
AVHVXKAONMHRSS-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Angiopoietin 1 receptor | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathwayP00005:Angiogenesis | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling | |||||
| References | |||||
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