Drug Information

Drug General Information
Drug ID
DX7OBM
Drug Name
2-[4-(Benzoylamino-methyl)-thiophene-2-sulfonyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide
Synonyms
CHEMBL343326
Indication Discovery agent Investigative [1587926]
Formula
C22H21N3O5S2
Canonical SMILES
ONC(=O)C1Cc2ccccc2CN1S(=O)(=O)c3cc(CNC(=O)c4ccccc4)cs3
InChI
InChI=1S/C22H21N3O5S2/c26-21(16-6-2-1-3-7-16)23-12-15-10-20(31-14-15)32(29,30)25-13-18-9-5-4-8-17(18)11-19(25)22(27)24-28/h1-10,14,19,28H,11-13H2,(H,23,26)(H,24,27)
InChIKey
IMRWXXAPWNPDGA-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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