Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXX4F0
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| Drug Name |
2-[4-(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-phenoxy]-benzoic acid
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| Synonyms |
CHEMBL67211
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C22H20N4O3
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| Canonical SMILES |
CC(C)n1cc(c2ccc(Oc3ccccc3C(=O)O)cc2)c4c(N)ncnc14
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| InChI |
InChI=1S/C22H20N4O3/c1-13(2)26-11-17(19-20(23)24-12-25-21(19)26)14-7-9-15(10-8-14)29-18-6-4-3-5-16(18)22(27)28/h3-13H,1-2H3,(H,27,28)(H2,23,24,25)
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| InChIKey |
HJWSKMQXMBSGEX-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Angiopoietin 1 receptor | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathwayP00005:Angiogenesis | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling | |||||
| References | |||||
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