Drug Information

Drug General Information
Drug ID
DXQ2MQ
Drug Name
2-(5-Pyridin-2-yl-thiophen-2-ylmethanesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide
Synonyms
CHEMBL140602
Indication Discovery agent Investigative [1587926]
Formula
C20H19N3O4S2
Canonical SMILES
ONC(=O)C1Cc2ccccc2CN1S(=O)(=O)Cc3ccc(s3)c4ccccn4
InChI
InChI=1S/C20H19N3O4S2/c24-20(22-25)18-11-14-5-1-2-6-15(14)12-23(18)29(26,27)13-16-8-9-19(28-16)17-7-3-4-10-21-17/h1-10,18,25H,11-13H2,(H,22,24)
InChIKey
OGWVESDVKZYNCK-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.