Drug Information

Drug General Information
Drug ID
DX1QPF
Drug Name
2-(4-Benzenesulfonyl-thiophene-2-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide
Synonyms
CHEMBL343547
Indication Discovery agent Investigative [1587926]
Formula
C20H18N2O6S3
Canonical SMILES
ONC(=O)C1Cc2ccccc2CN1S(=O)(=O)c3cc(cs3)S(=O)(=O)c4ccccc4
InChI
InChI=1S/C20H18N2O6S3/c23-20(21-24)18-10-14-6-4-5-7-15(14)12-22(18)31(27,28)19-11-17(13-29-19)30(25,26)16-8-2-1-3-9-16/h1-9,11,13,18,24H,10,12H2,(H,21,23)
InChIKey
BAAHKTZFKMCWLC-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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