| Drug General Information |
| Drug ID |
DX0Q8X
|
| Drug Name |
2-(2,3-dimethyl-4-(2-(pyridin-4-ylmethoxy)-4-((4-(trifluoromethyl)phenoxy)methyl)phenylthio)phenoxy)acetic acid
|
| Synonyms |
CHEMBL501979
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Formula |
C30H26F3NO5S
|
| Canonical SMILES |
Cc1c(C)c(Sc2ccc(COc3ccc(cc3)C(F)(F)F)cc2OCc4ccncc4)ccc1OCC(=O)O
|
| InChI |
InChI=1S/C30H26F3NO5S/c1-19-20(2)27(10-8-25(19)39-18-29(35)36)40-28-9-3-22(15-26(28)38-16-21-11-13-34-14-12-21)17-37-24-6-4-23(5-7-24)30(31,32)33/h3-15H,16-18H2,1-2H3,(H,35,36)
|
| InChIKey |
QOVRZVRUKFJQMJ-UHFFFAOYSA-N
|
| Target and Pathway |
| Target(s) |
Peroxisome proliferator activated receptor gamma |
Target Info |
|
[1]
|
|---|
| Peroxisomeproliferator activated receptor delta |
Target Info |
|
[1]
|
|
KEGG Pathway
|
PPAR signaling pathway
|
|
AMPK signaling pathway
|
|
Osteoclast differentiation
|
|
Huntington's disease
|
|
Pathways in cancer
|
|
Transcriptional misregulation in cancer
|
|
Thyroid cancerhsa03320:PPAR signaling pathway
|
|
Wnt signaling pathway
|
|
Acute myeloid leukemia
|
|
NetPath Pathway
|
IL1 Signaling Pathway
|
|
TGF_beta_Receptor Signaling Pathway
|
|
Leptin Signaling PathwayNetPath_14:IL2 Signaling Pathway
|
|
PANTHER Pathway
|
CCKR signaling map STP00057:Wnt signaling pathway
|
|
Pathway Interaction Database
|
Noncanonical Wnt signaling pathway
|
|
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
|
|
Signaling events mediated by HDAC Class I
|
|
RXR and RAR heterodimerization with other nuclear receptor
|
|
Regulation of retinoblastoma proteinps1pathway:Presenilin action in Notch and Wnt signaling
|
|
Reactome
|
PPARA activates gene expression
|
|
Transcriptional regulation of white adipocyte differentiation
|
|
Nuclear Receptor transcription pathwayR-HSA-200425:Import of palmitoyl-CoA into the mitochondrial matrix
|
|
Regulation of pyruvate dehydrogenase (PDH) complex
|
|
Nuclear Receptor transcription pathway
|
|
WikiPathways
|
Wnt Signaling Pathway Netpath
|
|
Nuclear Receptors in Lipid Metabolism and Toxicity
|
|
Differentiation of white and brown adipocyte
|
|
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
|
|
Transcriptional Regulation of White Adipocyte Differentiation
|
|
Adipogenesis
|
|
SREBP signalling
|
|
Nuclear ReceptorsWP399:Wnt Signaling Pathway and Pluripotency
|
|
NRF2 pathway
|
|
Nuclear Receptors Meta-Pathway
|
|
Vitamin D Receptor Pathway
|
|
Ectoderm Differentiation
|
|
Nuclear Receptors
|
| References |
| REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 |
|---|
