Drug General Information |
Drug ID |
DXZG6T
|
Drug Name |
2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one
|
Synonyms |
CHEMBL1241767
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Formula |
C28H23N7O2
|
Canonical SMILES |
Cc1ccccc1N2C(=Nc3cccc(C)c3C2=O)Cn4nc(c5cccc(O)c5)c6c(N)ncnc46
|
InChI |
InChI=1S/C28H23N7O2/c1-16-7-3-4-12-21(16)35-22(32-20-11-5-8-17(2)23(20)28(35)37)14-34-27-24(26(29)30-15-31-27)25(33-34)18-9-6-10-19(36)13-18/h3-13,15,36H,14H2,1-2H3,(H2,29,30,31)
|
InChIKey |
WFSLJOPRIJSOJR-UHFFFAOYSA-N
|
Target and Pathway |
Target(s) |
Phosphoinositide 3 kinase |
Target Info |
|
[1]
|
PI3K delta |
Target Info |
|
[1]
|
BioCyc Pathway
|
Superpathway of inositol phosphate compounds
|
3-phosphoinositide biosynthesis
|
KEGG Pathway
|
Inositol phosphate metabolism
|
ErbB signaling pathway
|
Ras signaling pathway
|
Rap1 signaling pathway
|
cGMP-PKG signaling pathway
|
cAMP signaling pathway
|
Chemokine signaling pathway
|
HIF-1 signaling pathway
|
FoxO signaling pathway
|
Phosphatidylinositol signaling system
|
Sphingolipid signaling pathway
|
mTOR signaling pathway
|
PI3K-Akt signaling pathway
|
AMPK signaling pathway
|
Apoptosis
|
Adrenergic signaling in cardiomyocytes
|
VEGF signaling pathway
|
Osteoclast differentiation
|
Focal adhesion
|
Signaling pathways regulating pluripotency of stem cells
|
Platelet activation
|
Toll-like receptor signaling pathway
|
Jak-STAT signaling pathway
|
Natural killer cell mediated cytotoxicity
|
T cell receptor signaling pathway
|
B cell receptor signaling pathway
|
Fc epsilon RI signaling pathway
|
Fc gamma R-mediated phagocytosis
|
TNF signaling pathway
|
Leukocyte transendothelial migration
|
Neurotrophin signaling pathway
|
Cholinergic synapse
|
Inflammatory mediator regulation of TRP channels
|
Regulation of actin cytoskeleton
|
Insulin signaling pathway
|
Progesterone-mediated oocyte maturation
|
Estrogen signaling pathway
|
Prolactin signaling pathway
|
Thyroid hormone signaling pathway
|
Oxytocin signaling pathway
|
Regulation of lipolysis in adipocytes
|
Type II diabetes mellitus
|
Non-alcoholic fatty liver disease (NAFLD)
|
Aldosterone-regulated sodium reabsorption
|
Carbohydrate digestion and absorption
|
Bacterial invasion of epithelial cells
|
Chagas disease (American trypanosomiasis)
|
Toxoplasmosis
|
Amoebiasis
|
Hepatitis C
|
Hepatitis B
|
Measles
|
Influenza A
|
HTLV-I infection
|
Epstein-Barr virus infection
|
Pathways in cancer
|
Viral carcinogenesis
|
Proteoglycans in cancer
|
MicroRNAs in cancer
|
Colorectal cancer
|
Renal cell carcinoma
|
Pancreatic cancer
|
Endometrial cancer
|
Glioma
|
Prostate cancer
|
Melanoma
|
Chronic myeloid leukemia
|
Acute myeloid leukemia
|
Small cell lung cancer
|
Non-small cell lung cancer
|
Central carbon metabolism in cancer
|
Choline metabolism in cancerhsa00562:Inositol phosphate metabolism
|
Choline metabolism in cancer
|
NetPath Pathway
|
FSH Signaling Pathway
|
PANTHER Pathway
|
Angiogenesis
|
Apoptosis signaling pathway
|
Axon guidance mediated by netrin
|
B cell activation
|
EGF receptor signaling pathway
|
Endothelin signaling pathway
|
FGF signaling pathway
|
Hypoxia response via HIF activation
|
Inflammation mediated by chemokine and cytokine signaling pathway
|
Insulin/IGF pathway-protein kinase B signaling cascade
|
Integrin signalling pathway
|
PDGF signaling pathway
|
T cell activation
|
VEGF signaling pathway
|
p53 pathway
|
Ras Pathway
|
p53 pathway feedback loops 2
|
Pathway Interaction Database
|
ErbB4 signaling events
|
TRAIL signaling pathway
|
Signaling events mediated by TCPTP
|
FAS (CD95) signaling pathway
|
CXCR4-mediated signaling events
|
EGF receptor (ErbB1) signaling pathway
|
Class I PI3K signaling events
|
ErbB1 downstream signaling
|
ErbB2/ErbB3 signaling events
|
PDGFR-beta signaling pathway
|
Nephrin/Neph1 signaling in the kidney podocyte
|
Internalization of ErbB1
|
CXCR3-mediated signaling events
|
PathWhiz Pathway
|
Inositol Metabolism
|
Phosphatidylinositol Phosphate Metabolism
|
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
Fc Epsilon Receptor I Signaling in Mast CellsPW000168:Phosphatidylinositol Phosphate Metabolism
|
Reactome
|
PI3K Cascade
|
GPVI-mediated activation cascade
|
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
|
PI3K events in ERBB4 signaling
|
PIP3 activates AKT signaling
|
GAB1 signalosome
|
PI3K events in ERBB2 signaling
|
PI3K/AKT activation
|
Role of phospholipids in phagocytosis
|
Tie2 Signaling
|
Constitutive Signaling by Aberrant PI3K in Cancer
|
DAP12 signaling
|
Role of LAT2/NTAL/LAB on calcium mobilization
|
Nephrin interactions
|
Costimulation by the CD28 family
|
CD28 dependent PI3K/Akt signaling
|
G beta:gamma signalling through PI3Kgamma
|
G alpha (q) signalling events
|
G alpha (12/13) signalling events
|
VEGFA-VEGFR2 Pathway
|
Interleukin-3, 5 and GM-CSF signaling
|
Constitutive Signaling by EGFRvIII
|
PI-3K cascade:FGFR1
|
PI-3K cascade:FGFR2
|
PI-3K cascade:FGFR3
|
PI-3K cascade:FGFR4
|
Interleukin receptor SHC signaling
|
Regulation of signaling by CBLR-HSA-114604:GPVI-mediated activation cascade
|
Regulation of signaling by CBL
|
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
|
WikiPathways
|
Toll-like receptor signaling pathway
|
Serotonin HTR1 Group and FOS Pathway
|
DNA Damage Response (only ATM dependent)
|
G13 Signaling Pathway
|
Regulation of Actin Cytoskeleton
|
Insulin Signaling
|
IL-4 Signaling Pathway
|
Copper homeostasis
|
Signaling of Hepatocyte Growth Factor Receptor
|
Transcriptional activation by NRF2
|
IL1 and megakaryotyces in obesity
|
Signaling by ERBB4
|
Signaling by ERBB2
|
Fc epsilon receptor (FCERI) signaling
|
PI Metabolism
|
Interleukin-2 signaling
|
Fcgamma receptor (FCGR) dependent phagocytosis
|
Signaling by SCF-KIT
|
DAP12 interactions
|
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
PIP3 activates AKT signaling
|
Integrated Pancreatic Cancer Pathway
|
Prostate Cancer
|
Signaling Pathways in Glioblastoma
|
TSLP Signaling Pathway
|
Regulation of Microtubule Cytoskeleton
|
TSH signaling pathway
|
SREBP signalling
|
TCR signaling
|
Signaling by PDGF
|
Signaling by Insulin receptor
|
Signaling by FGFR
|
Signaling by EGFR
|
NGF signalling via TRKA from the plasma membrane
|
Nephrin interactions
|
Interleukin-3, 5 and GM-CSF signaling
|
GPVI-mediated activation cascade
|
GPCR downstream signaling
|
Costimulation by the CD28 family
|
Cell surface interactions at the vascular wall
|
MicroRNAs in cardiomyocyte hypertrophy
|
Angiogenesis
|
Regulation of toll-like receptor signaling pathway
|
AMPK SignalingWP75:Toll-like receptor signaling pathway
|
Interferon type I signaling pathways
|
Focal Adhesion
|
IL-3 Signaling Pathway
|
Signaling by the B Cell Receptor (BCR)
|
Nanoparticle-mediated activation of receptor signaling
|
AMPK Signaling
|
References |
REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 |