Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXF1IZ
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| Drug Name |
1-(4-(4-amino-6-isopropylthieno[2,3-d]pyrimidin-5-yl)phenyl)-3-m-tolylurea
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| Synonyms |
CHEMBL371890
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C23H23N5OS
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| Canonical SMILES |
CC(C)c1sc2ncnc(N)c2c1c3ccc(NC(=O)Nc4cccc(C)c4)cc3
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| InChI |
InChI=1S/C23H23N5OS/c1-13(2)20-18(19-21(24)25-12-26-22(19)30-20)15-7-9-16(10-8-15)27-23(29)28-17-6-4-5-14(3)11-17/h4-13H,1-3H3,(H2,24,25,26)(H2,27,28,29)
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| InChIKey |
VNWDQYGXWXVPJM-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Angiopoietin 1 receptor | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathwayP00005:Angiogenesis | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling | |||||
| References | |||||
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