Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXAK7J
|
||||
| Drug Name |
1-(2-methoxyethyl)-1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)methyl)-3-m-tolylurea
|
||||
| Synonyms |
CHEMBL213270
|
||||
| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C32H38N6O2S
|
||||
| Canonical SMILES |
COCCN(Cc1ccc(s1)c2[nH]nc3c2Cc4cc(CN5CCN(C)CC5)ccc34)C(=O)Nc6cccc(C)c6
|
||||
| InChI |
InChI=1S/C32H38N6O2S/c1-22-5-4-6-25(17-22)33-32(39)38(15-16-40-3)21-26-8-10-29(41-26)31-28-19-24-18-23(7-9-27(24)30(28)34-35-31)20-37-13-11-36(2)12-14-37/h4-10,17-18H,11-16,19-21H2,1-3H3,(H,33,39)(H,34,35)
|
||||
| InChIKey |
JPWOUJQSSZSAEC-UHFFFAOYSA-N
|
||||
| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Vascular endothelial growth factor receptor 1 | Target Info | [1587926] | |||
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| Cytokine-cytokine receptor interaction | |||||
| Endocytosis | |||||
| PI3K-Akt signaling pathway | |||||
| VEGF signaling pathway | |||||
| Focal adhesion | |||||
| Proteoglycans in cancerhsa04014:Ras signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Transcriptional misregulation in cancer | |||||
| Rheumatoid arthritis | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathway | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkglypican_1pathway:Glypican 1 network | |||||
| S1P3 pathway | |||||
| VEGFR1 specific signals | |||||
| References | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.