Drug Information

Drug General Information
Drug ID
DXY9WM
Drug Name
[6-tert-Butoxycarbonylamino-2-(4'-fluoro-biphenyl-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid
Synonyms
CHEMBL137900
Indication Discovery agent Investigative [1587926]
Formula
C28H27FN2O7S
Canonical SMILES
CC(C)(C)OC(=O)Nc1ccc2CN(C(Cc2c1)C(=O)C(=O)O)S(=O)(=O)c3ccc(cc3)c4ccc(F)cc4
InChI
InChI=1S/C28H27FN2O7S/c1-28(2,3)38-27(35)30-22-11-6-19-16-31(24(15-20(19)14-22)25(32)26(33)34)39(36,37)23-12-7-18(8-13-23)17-4-9-21(29)10-5-17/h4-14,24H,15-16H2,1-3H3,(H,30,35)(H,33,34)
InChIKey
LERSXUYNVGTZOT-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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