Drug Information

Drug General Information
Drug ID
DX0PRZ
Drug Name
[4-(3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinoline-2-sulfonyl)-phenyl]-carbamic acid benzyl ester
Synonyms
CHEMBL342889
Indication Discovery agent Investigative [1587926]
Formula
C24H23N3O6S
Canonical SMILES
ONC(=O)C1Cc2ccccc2CN1S(=O)(=O)c3ccc(NC(=O)OCc4ccccc4)cc3
InChI
InChI=1S/C24H23N3O6S/c28-23(26-30)22-14-18-8-4-5-9-19(18)15-27(22)34(31,32)21-12-10-20(11-13-21)25-24(29)33-16-17-6-2-1-3-7-17/h1-13,22,30H,14-16H2,(H,25,29)(H,26,28)
InChIKey
IKSAVMPIZWWMKE-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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