Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX6THD
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| Drug Name |
[4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid ethyl ester
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| Synonyms |
CHEMBL366019
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C20H22F2N6O4
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| Canonical SMILES |
CCOC(=O)Nc1cn2ncnc(Nc3cc(C(=O)NOC)c(F)cc3F)c2c1C(C)C
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| InChI |
InChI=1S/C20H22F2N6O4/c1-5-32-20(30)26-15-8-28-17(16(15)10(2)3)18(23-9-24-28)25-14-6-11(19(29)27-31-4)12(21)7-13(14)22/h6-10H,5H2,1-4H3,(H,26,30)(H,27,29)(H,23,24,25)
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| InChIKey |
KULLGNXUHQGZIB-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Vascular endothelial growth factor receptor 1 | Target Info | [1587926] | |||
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| Cytokine-cytokine receptor interaction | |||||
| Endocytosis | |||||
| PI3K-Akt signaling pathway | |||||
| VEGF signaling pathway | |||||
| Focal adhesion | |||||
| Proteoglycans in cancerhsa04014:Ras signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Transcriptional misregulation in cancer | |||||
| Rheumatoid arthritis | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathway | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkglypican_1pathway:Glypican 1 network | |||||
| S1P3 pathway | |||||
| VEGFR1 specific signals | |||||
| References | |||||
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