Drug Information

Drug General Information
Drug ID
DX8BCS
Drug Name
[2-(4-Methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid
Synonyms
CHEMBL424106
Indication Discovery agent Investigative [1587926]
Formula
C18H17NO6S
Canonical SMILES
COc1ccc(cc1)S(=O)(=O)N2Cc3ccccc3CC2C(=O)C(=O)O
InChI
InChI=1S/C18H17NO6S/c1-25-14-6-8-15(9-7-14)26(23,24)19-11-13-5-3-2-4-12(13)10-16(19)17(20)18(21)22/h2-9,16H,10-11H2,1H3,(H,21,22)
InChIKey
GEFPLKDZRKGIKM-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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