Drug Information

Drug General Information
Drug ID
DX6EKQ
Drug Name
[2-(2-Biphenyl-4-yl-ethanesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid
Synonyms
CHEMBL335118
Indication Discovery agent Investigative [1587926]
Formula
C25H23NO5S
Canonical SMILES
OC(=O)C(=O)C1Cc2ccccc2CN1S(=O)(=O)CCc3ccc(cc3)c4ccccc4
InChI
InChI=1S/C25H23NO5S/c27-24(25(28)29)23-16-21-8-4-5-9-22(21)17-26(23)32(30,31)15-14-18-10-12-20(13-11-18)19-6-2-1-3-7-19/h1-13,23H,14-17H2,(H,28,29)
InChIKey
XTRJAENNSAJIAU-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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